Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

If you love creamy pasta with a kick, this Creamy Cajun Chicken Spaghetti will absolutely steal the show. It’s a perfect balance of spicy, cheesy, and comforting — tender bites of seasoned chicken tossed with spaghetti in a rich garlic mozzarella cream sauce that’s irresistibly smooth and decadent.

It’s like your favorite Cajun Alfredo meets cheesy garlic pasta — and it’s all made in under an hour! This is the kind of dish that feels like it came from a restaurant, but it’s easy enough for any weeknight dinner.

Ingredients

For the Chicken:

• 1 pound boneless, skinless chicken breasts, cut into bite-sized pieces
• 2 tablespoons olive oil
• 1 tablespoon Cajun seasoning (store-bought or homemade — see tip below)
• Salt and black pepper, to taste

For the Pasta:

• 1 pound spaghetti (or fettuccine)
• Salt, for boiling water

For the Garlic Mozzarella Sauce:

• 4 tablespoons butter
• 4 cloves garlic, minced
• 3 cups whole milk (or 2 cups milk + 1 cup heavy cream for extra richness)
• 1 cup chicken broth
• 8 ounces cream cheese, softened
• 2 cups shredded mozzarella cheese, divided
• ½ cup grated Parmesan cheese
• 1 teaspoon Cajun seasoning (to taste)
• ¼ teaspoon crushed red pepper flakes (optional, for heat)
• Salt and pepper, to taste
• Fresh parsley or green onions, for garnish

Instructions

Step 1: Cook the Spaghetti

1. Bring a large pot of salted water to a boil.
2. Cook the spaghetti according to package directions until al dente.
3. Reserve 1 cup of pasta water, then drain and set aside.
4. Drizzle a little olive oil over the pasta to prevent sticking.

Step 2: Cook the Cajun Chicken

1. In a large skillet, heat olive oil over medium-high heat.
2. Season the chicken pieces with Cajun seasoning, salt, and pepper.
3. Add the chicken to the skillet and cook for about 5–7 minutes, stirring occasionally, until golden and fully cooked through.
4. Transfer to a plate and set aside.
5. Tip: Want more authentic Cajun flavor? Add a pinch of smoked paprika and cayenne for extra depth.

Step 3: Make the Garlic Mozzarella Sauce

1. In the same skillet, reduce the heat to medium and melt the butter.
2. Add the minced garlic and sauté for about 30 seconds, just until fragrant (don’t let it brown).
3. Pour in the chicken broth and milk, whisking constantly.
4. Add the cream cheese, stirring until it melts and becomes smooth and creamy.
5. Stir in 1½ cups mozzarella, Parmesan, and Cajun seasoning.
6. Let the sauce simmer gently for 3–5 minutes, whisking occasionally, until thickened to your liking.
7.  Don’t let the sauce boil — it can cause the dairy to separate. Gentle simmering keeps it smooth and silky!

Step 4: Combine Everything

1. Add the cooked chicken back into the skillet and toss to coat it in the sauce.
2. Add the cooked spaghetti, stirring gently until it’s fully coated in that creamy Cajun cheese sauce.
3. If the sauce feels too thick, add a splash of the reserved pasta water to loosen it up.

Step 5: Add the Finishing Touches

1. Sprinkle the remaining ½ cup mozzarella cheese over the top.
2. Cover the skillet and let it sit on low heat for 1–2 minutes, just until the cheese melts into gooey perfection.
3. Garnish with fresh parsley or sliced green onions before serving.

Homemade Cajun Seasoning (Optional)

If you’d like to make your own, here’s a quick blend:

• 1 tablespoon paprika
• 1 teaspoon garlic powder
• 1 teaspoon onion powder
• 1 teaspoon dried oregano
• 1 teaspoon dried thyme
• ½ teaspoon cayenne pepper
• ½ teaspoon black pepper
• ½ teaspoon salt

Mix and store in an airtight jar — perfect for chicken, shrimp, or pasta dishes.

Serving Suggestions

Serve your Creamy Cajun Chicken Spaghetti with:

• A side of garlic bread or buttery Texas toast
• A simple Caesar or green salad for balance
• Roasted or steamed veggies, like broccoli or asparagus

And of course — a sprinkle of extra Parmesan never hurts!

Storage & Reheating

• Refrigerate: Store leftovers in an airtight container for up to 4 days.
• Reheat: Warm gently on the stove over low heat with a splash of milk or broth to loosen the sauce.
• Freeze: This dish freezes well! Freeze for up to 2 months — thaw overnight in the fridge before reheating.

Final Thoughts

This Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce is everything you want in a comfort meal — rich, spicy, and full of creamy goodness. The combination of Cajun seasoning, melted cheese, and tender chicken creates an unforgettable dish that feels indulgent yet easy enough for any night of the week.

It’s a guaranteed crowd-pleaser — comforting, bold, and utterly satisfying.